Novel human-cell based assay for assessment of cardiovascular liability.
Disease Prevention, Therapeutics and Diagnostics is a research theme within the Centre for Sport, Excerise and Life Sciences.
This is a cross-cutting theme aimed at novel scientific and clinical approaches to support the development of modern-day therapeutics discovery and development, and disease prevention.
We have expertise in areas including; target selection and validation, lead molecule identification and optimisation, computational drug design and disease modelling. This incorporates the work being done by Professor Mark Wheatley, who has an international reputation for his research into the structure and function of G-protein-coupled receptors (GPCRs).
Our interests include SARS-CoV-2, the immune response, metabolic disease, cardiovascular disease, cardioprotective strategies and drug safety.
We develop, test and implement clinical diagnostic, therapeutic and complex behaviour change interventions to improve health and healthcare in the community and NHS settings.
If you wish to find out more about this theme, please get in contact with Professor Chris Reynolds.
Our vision: Improving society by innovative collaborative health-related research.
Our mission: To carry out high quality basic and applied research that underpins disease prevention and new therapies.
|Professor Christopher Reynolds||Theme Leadfirstname.lastname@example.org|
|Professor Richard Aspinall||Associate Deanemail@example.com|
|Dr Elizabeth Bailey||Research Fellow Midwifefirstname.lastname@example.org|
|Eliot Barson||ASPiRE Fellowemail@example.com|
|Dr Bernie Burke||Associate Professorfirstname.lastname@example.org|
|Professor Jane Coad||Emeritus Professoremail@example.com|
|Dr Giuseppe Deganutti||Research Fellowfirstname.lastname@example.org|
|Professor Helen Maddock||Executive Directoremail@example.com|
|Dr Hardip Sandhu||Assistant Professorfirstname.lastname@example.org|
|Dr Mark Turner||Research Fellowemail@example.com|
Researchers in this theme take novel scientific and clinical approaches to supporting the development of modern-day therapeutics discovery and development.
Find out more about some of our projects:
Using molecular dynamics (MD) simulations to understand more fully the conformational landscape of GPCRs in the presence of agonist.
Developing a Markov state model of the ligand binding process and how this leads to activation.