Investigating GPCR:RAMP
G-protein-coupled receptors (GPCRs) and complexes with accessory proteins (RAMPs) will be purified in nanoscale discs. These will be used to develop small antibodies (nanobodies) as tools for investigating receptor function.
Cell Signalling and Membrane Biology
Cell Signalling and Membrane Biology is a research theme within the Centre for Sport, Exercise and Life Sciences.
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Focus of our research
Research within this theme focuses on understanding fundamental molecular mechanisms to provide novel insights into cellular processes and their regulation.
This includes receptors, cell signalling, development of organisms, their interaction with pathogens, plus the molecular basis and pathophysiology of diseases including cancer and metabolic disorders, as well as signalling and transcriptional pathways in normal and pathological states.
We exploit multi-disciplinary approaches including molecular biology, cell and developmental biology, biochemical pharmacology, confocal microscopy, genetics/epigenetics, computational and systems biology.
If you wish to find out more about this theme, please get in contact with Professor Mark Wheatley.
Vision statement
Our vision: Improving health through a detailed understanding of molecules and cells.
Mission statement
Our mission: To investigating cellular mechanisms to benefit human health.
Key researchers
| Name | Title | |
|---|---|---|
| Professor Mark Wheatley | Theme lead, Professor of Biochemical Pharmacology | mark.wheatley@coventry.ac.uk |
| Dr Hoor Ayub | Research Fellow | hoor.ayub@coventry.ac.uk |
| Dr Jason Bennett | Assistant Professor | jason.bennett@coventry.ac.uk |
| Dr Mike Dodd | Assistant Professor | mike.dodd@coventry.ac.uk |
| Dr Jennifer Greaves | Assistant Professor | jennifer.greaves@coventry.ac.uk |
| Dr Igor Morozov | Assistant Professor | igor.morozov@coventry.ac.uk |
| Dr Anne Reiman | Assistant Professor | anne.reiman@coventry.ac.uk |
| Dr Romez Uddin | Research Fellow | romez.uddin@coventry.ac.uk |
Project spotlight
Our research aims to increase our understanding of fundamental molecular mechanisms to provide novel insights into cellular processes and their regulation for the benefit of human health.
Find out more about some of our projects:
Investigating the function and substrate interaction network of ABHD16A
ABHD16A, a known phosphatatidylserine-lipase involved in neuroimmunological function, was recently identified as a novel, selective APT. This study aims to characterise the molecular mechanisms and functions of a novel APT, ABHD16A.
Transition state analysis to guide drug discovery
Exploiting and developing a new state-of-the-art computational model that makes it possible to predict how well a drug will bind to its receptor, how the receptor will change shape, and which signalling pathways it will activate.
