MY RESEARCH VISION
As an early career researcher I have worked in many fields and have a wide range of technical experience. More recently I have taken advantage of my molecular expertise to investigate the role of mitochondrial mutations as a potential biomarker for aging, more specifically oxidative stress-induced damage.
My research interests focus on the response of skin to ultraviolet radiation (UV) specifically the use of mitochondrial DNA as a biomarker of UV exposure, the role of mitochondria in UV-induced oxidative stress and the potential use of antioxidants to reduce damage.
- Lane, S., Al-Zubiedi, S., Hatch, E., Matthews, I., Jorgensen, A.L., Deloukas, P., Daly, A.K., Park, B.K., Aarons, L., Ogungbenro, K., Kamali, F., Hughes, D., and Pirmohamed, M. (2011) 'The Population Pharmacokinetics of R and S-Warfarin: Effect of Genetic and Clinical Factors'. British Journal of Clinical Pharmacology 73 (1), 66-76.
- Tang, Z., Lu, B., Hatch, E., Sacks, S.H., and Sheerin, N.S. (2009) 'C3a mediates epithelial-to-mesenchymal transition in proteinuric nephropathy'. Journal of the American Society of Nephrology 20 (3), 593-603.
- Hatch, E., Wynne, H., Avery, P., Wadelius, M., and Kamali, F. (2008) 'Application of a pharmacogenetic-based warfarin dosing algorithm derived from British patients to predict dose in Swedish patients'. Journal of Thrombosis and Haemostasis 6 (6), 1038-1040.
- Hatch, E., Sconce, E.A., Daly, A.K., and Kamali, F. (2006) 'A rapid genotyping method for the vitamin K epoxide reductase complex subunit 1 (VKORC1) gene'. Journal of Thrombosis and Haemostasis 4, 1158-1159.