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Addressing GPCR conformational flexibility
The large G protein coupled receptor (GPCR) family is a highly interesting target for drug design because a large proportion of current drugs bind to its members, and because the family offers much potential to exploit new targets.
PostUraL tachycardia Syndrome Exercise (PulSE) study
A lifestyle intervention designed by people with POTS, for people with POTS.
Bioleaching technology for the recovery of metals from Electronic Waste - Research Project
The aim of the project is to develop a sustainable and environmentally friendly method to recover precious metals from electronic waste that will create a closed-loop system to recycle metals back into the supply chain as required in a sustainable circular economy.
Feed Me How? A study of confidence and competence related to gastrostomy care and blended diet
The ‘Feed Me How’ project was implemented to evaluate the ICF on-line competency-based programme of learning around gastrostomy care with health professionals across the UK using a mixed methods and survey approach.
Work-Loop marketing assessment
A Pathfinder II Investment is intended to produce a fully viable proposition ready for seed investment.
InoCardia: Novel human-cell based assay for assessment of cardiovascular liability
The aim of this project was to test the concept of a higher throughput functional cardiac cell contractile assay under truly physiological conditions, advancing information on how the heart behaves functionally and enabling the testing of inotropic drugs in these conditions.
Through the eyes of children, young people and families - Evaluation of the model of care delivered by WellChild Nurses
This project carried out a longitudinal evaluation of the model of care delivered to children, young people and families with complex care needs by organisation WellChild.
Review of Evidence on the Physiological and Psychological Development of Children
In 2015 the UK Government gave Sport England a new remit to support children aged 5-14 years. SE commissioned Duncan, Eyre and colleagues to undertake a review (completed in March 2017) to inform the body’s response to this.
Clinical Academic Research Development (CARD)
The main focus of CARD is to support allied health professionals working in the NHS undertake translational research, particularly in the field of nursing.
InoCardia: Delivering Improved Cardiac Safety Liabilities for Therapeutic Drugs Using the Contractome-AI
The commercialisation of Professor Maddock's academic research started with a vision that there was a fundamental need within the Pharmaceutical Industry for the development of improved physiological relevant model to assess cardiac contractility.
Fundamental Movement Skills, Physical Activity and Obesity in British Children
This project aims to understand how early development of fundamental movement skills might impact on physical activity and body fatness in British children.
The Blended Diet Study: the perceived benefits and risk of using a blended diet with children and young people with complex health needs and enteral feeding requirements
The use of a blended diet as an alternative to prescribed formula feeds has provoked strong opinion in research and among professionals. The aims of the report will be to examine the evidence for best practice with regards to providing a blended diet via gastrostomy tube.
Teenage Cancer Trust North-West Pilot Site Evaluation: A participatory action research project in the NW of England evaluating Teenage and Young Adult cancer services
Coventry University were tasked with providing a longitudinal evaluation of the Teenage Cancer Trust's pilot scheme in the North West.
Using novel computational modelling approaches to address biased agonism at the Adenosine A1 receptor
We seek to apply cutting-edge advanced sampling molecular dynamics simulations to address the complex biological issue of how G protein-coupled receptors (GPCRs) transition between multiple active states.
Coffee Ingestion: Interaction Between Sex and Cycling Performance
The aim of this study was to investigate whether sex differences exist with regard to 5 km cycling time trial performance and affective responses following the ingestion of 300 ml caffeinated coffee, a placebo (coffee flavoured solution) and a control (no fluid).
Investigating GPCR:RAMP interactions using nanobodies
Professor Mark Wheatley and collaborators have been awarded a grant from the BBSRC to investigate the G-protein-coupled receptor (GPCR) family of proteins.
Skeletal muscle fatigue during locomotion
This project aimed to investigate various potential mechanisms of skeletal muscle fatigue that might explain the limits of locomotor performance observed in animals.
InoCardia: Human Traberculae Work-Loop Feasibility
The aim of this project was to develop a test that uses human heart muscle tissue in a way that can efficiently test many drugs, to reduce the risk of any approved drugs causing damage to the heart.
Bioleaching technology for the recovery of metals from Electronic Waste
Applications to Bioleaching technology to extract precious metals from Waste Electrical and Electronic Equipment (WEEE), whilst preserving the environment and preventing health-related issues worldwide.
The Effectiveness of a Primary School Based Badminton Intervention on Children’s Fundamental Movement Skills
This project examined if a badminton based intervention is effective in enhancing fundamental movement skills, physical activity, motivation to undertake physical activity, fitness and health in children aged 7-9 years.