InoCardia: Delivering Improved Cardiac Safety Liabilities for Therapeutic Drugs Using the Contractome-AI

The commercialisation of Professor Maddock's academic research started with a vision that there was a fundamental need within the Pharmaceutical Industry for the development of improved physiological relevant model to assess cardiac contractility.

Pilot of a teacher training intervention to deliver student-centred motor learning pedagogical approaches

This project is a pilot of a teacher training intervention to deliver student-centred motor learning pedagogical approaches and improve primary school children’s motor competence and motivation in physical education

Addressing GPCR conformational flexibility

The large G protein coupled receptor (GPCR) family is a highly interesting target for drug design because a large proportion of current drugs bind to its members, and because the family offers much potential to exploit new targets.

Bioleaching technology for the recovery of metals from Electronic Waste - Research Project

The aim of the project is to develop a sustainable and environmentally friendly method to recover precious metals from electronic waste that will create a closed-loop system to recycle metals back into the supply chain as required in a sustainable circular economy.

Clinical Academic Research Development (CARD)

The main focus of CARD is to support allied health professionals working in the NHS undertake translational research, particularly in the field of nursing.

PostUraL tachycardia Syndrome Exercise (PulSE) study

A lifestyle intervention designed by people with POTS, for people with POTS.

Great expectations: a predictive processing account of human balance control

This research considers ways we can deliberately “manipulate” our predictive brains by using various interventions to modify our beliefs/expectations about an important perceptual-motor skills.

Investigating GPCR:RAMP interactions using nanobodies

Professor Mark Wheatley and collaborators have been awarded a grant from the BBSRC to investigate the G-protein-coupled receptor (GPCR) family of proteins.

Bioleaching technology for the recovery of metals from Electronic Waste

Applications to Bioleaching technology to extract precious metals from Waste Electrical and Electronic Equipment (WEEE), whilst preserving the environment and preventing health-related issues worldwide.

6-0! Promoting health through recreational football

This project focused on enhancing physical activity with aging people through recreational football activities.

Transition state analysis to guide drug discovery

Professor Mark Wheatley and collaborators from Aston University, Dr John Simms and Professor David Poyner, have been awarded a grant of £177,497 from the BBSRC Follow-on Fund to develop new technology that will potentially revolutionise the drug discovery process.

Identification of novel double-stranded RNA elements in developing antibiotic resistance in the agricultural environment

The goal of the project is to identify and subsequently characterise the dsRNA dimension of the animal gut microflora (both the differential presence of antisense bound to mRNA and phage dsRNAs containing novel genetic information in response to AB pressure). Identification of novel functional dsRNAs (asRNA bound to its target and phage dsRNAs involved in AR) will mark a paradigm shift in our understanding of the development of AR and future approaches to treating infections.

Cytokine and growth factor mediated regulation of cell polarity in liver regeneration and fibrosis

Dr Christopher Mee's project looking at the ability of the liver to fully regenerate after injury.

Comparison of RR intervals and heart rate variability between disposable and reusable electrocardiography leads

The aim of the project is to assess heart rate variability using novel disposable ECG leads in healthy subjects, and to assess the agreement between heart rate variability measures obtained using disposable and reusable electrocardiography leads.

Investigating the function and substrate interaction network of ABHD16A, a novel regulator of protein S-acylation

This study aims to characterise the molecular mechanisms and functions of a novel APT, ABHD16A.

Concentration or composition that is the question! How do exogenous fatty acids contribute to changes in metabolic flexibility of skeletal muscle?

Using Real-Time Cell Metabolic Analysis to establish how physiological and pathophysiological concentrations of FA impact mitochondrial function, capacity and substrate utilisation in human skeletal muscle cells.