Allostery-driven G protein selectivity in the adenosine A1 receptor

The A1R is a high-value drug target but is linked to serious cardiovascular side effects because it activates multiple G proteins. 


Transition state analysis to guide drug discovery

Professor Mark Wheatley and collaborators from Aston University, Dr John Simms and Professor David Poyner, have been awarded a grant of £177,497 from the BBSRC Follow-on Fund to develop new technology that will potentially revolutionise the drug discovery process.


Great expectations: a predictive processing account of human balance control

This research considers ways we can deliberately “manipulate” our predictive brains by using various interventions to modify our beliefs/expectations about an important perceptual-motor skills.


PostUraL tachycardia Syndrome Exercise (PulSE) study

A lifestyle intervention designed by people with POTS, for people with POTS.


InoCardia: Delivering Improved Cardiac Safety Liabilities for Therapeutic Drugs Using the Contractome-AI

The commercialisation of Professor Maddock's academic research started with a vision that there was a fundamental need within the Pharmaceutical Industry for the development of improved physiological relevant model to assess cardiac contractility.


Cytokine and growth factor mediated regulation of cell polarity in liver regeneration and fibrosis

Dr Christopher Mee's project looking at the ability of the liver to fully regenerate after injury.


Investigating GPCR:RAMP interactions using nanobodies

Professor Mark Wheatley and collaborators have been awarded a grant from the BBSRC to investigate the G-protein-coupled receptor (GPCR) family of proteins.


6-0! Promoting health through recreational football

This project focused on enhancing physical activity with aging people through recreational football activities.


Clinical Academic Research Development (CARD)

The main focus of CARD is to support allied health professionals working in the NHS undertake translational research, particularly in the field of nursing.


Concentration or composition that is the question! How do exogenous fatty acids contribute to changes in metabolic flexibility of skeletal muscle?

Using Real-Time Cell Metabolic Analysis to establish how physiological and pathophysiological concentrations of FA impact mitochondrial function, capacity and substrate utilisation in human skeletal muscle cells.


Understanding the role of prolactin on neuronal metabolism and its implications for gestation and lactation conditions

The pituitary lactogenic hormone prolactin (Prl) has well recognised physiological actions in humans and rodents in lactation and reproduction.


Development of Bioleaching-based processes for the recovery of precious metals of processed waste from Superalloys

In partnership with AAS, Coventry University are developing innovative and sustainable bioleaching-based processes to recover critical metals from superalloy by-products at AAS. 


Identification of novel double-stranded RNA elements in developing antibiotic resistance in the agricultural environment

The goal of the project is to identify and subsequently characterise the dsRNA dimension of the animal gut microflora (both the differential presence of antisense bound to mRNA and phage dsRNAs containing novel genetic information in response to AB pressure). Identification of novel functional dsRNAs (asRNA bound to its target and phage dsRNAs involved in AR) will mark a paradigm shift in our understanding of the development of AR and future approaches to treating infections.


The Development of a framework and toolkit to support a physical activity for health pathway in England

The aim of the project is to develop a framework and valid tools that support the delivery of physical activity pathways across England. Physical activity pathways support people with/at risk of health conditions to become more active.


Pilot of a teacher training intervention to deliver student-centred motor learning pedagogical approaches

This project is a pilot of a teacher training intervention to deliver student-centred motor learning pedagogical approaches and improve primary school children’s motor competence and motivation in physical education


Investigating the function and substrate interaction network of ABHD16A, a novel regulator of protein S-acylation

This study aims to characterise the molecular mechanisms and functions of a novel APT, ABHD16A.


Comparison of RR intervals and heart rate variability between disposable and reusable electrocardiography leads

The aim of the project is to assess heart rate variability using novel disposable ECG leads in healthy subjects, and to assess the agreement between heart rate variability measures obtained using disposable and reusable electrocardiography leads.


SE Recycling (SER) Bioleaching KTP project for metal recovery from EV batteries

This partnership with SE-Recycling is developing sustainable bioleaching-based processes to recycle metals from Lithium-based batteries. This sustainable technology delivers a solution that retains precious metals in UK industry, with wider economic benefits including skills development and job creation.


Bioleaching technology for the recovery of metals from Electronic Waste - Research Project

The aim of the project is to develop a sustainable and environmentally friendly method to recover precious metals from electronic waste that will create a closed-loop system to recycle metals back into the supply chain as required in a sustainable circular economy.