New research from Coventry University could help detect circulatory diseases in patients more quickly

Wednesday 25 May 2022

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The Centre for Intelligent Healthcare (CIH) has established a specialist research facility at Coventry University’s Technology Park which is investigating the benefits of new equipment and techniques that could be used for microvascular imaging – generating pictures of the body’s smallest blood vessels.

The research will focus on how changes in our circulatory systems can be linked to early-stage disease including diabetes, cancer, autoimmune conditions and ageing of the arteries. Researchers will investigate how different colours of light can accurately assess blood flow, its temperature and composition, which can all help to detect circulatory problems non-invasively and cost-effectively.

The research will investigate new ways to assess the severity of the Raynaud’s phenomenon – a circulatory condition which causes fingers and toes to change colour when cold or anxious. While rarely considered serious on its own, it can sometimes be the first sign of more severe conditions.

Professor John Allen, Professor of Biosensors and Bioinstrumentation at the CIH and a former senior Clinical Scientist at Newcastle’s Freeman Hospital, is leading the research at the new facility. The research will be carried out in collaboration with consultant clinicians including rheumatologists at University Hospitals Coventry and Warwickshire and will look at how practical applications of the research could be used in the NHS.

Coventry University’s research is not only uncovering better diagnostic techniques, but also has applications in assessing health and wellbeing.

The concept of ‘vascular age’ – a metric of circulatory fitness measured by studying the stiffness of arteries or their reactivity - is a topic of international interest.

It is currently difficult to measure this reliably, so Coventry University is teaming up with other scientists, engineers and clinicians, through groups such as VascAgeNet, to discuss and develop low-cost accessible ways of assessing the health of one’s circulation. The techniques the team are using not only detect abnormal blood flow, but can accurately assess high-quality blood flow as well at very low costs.

Detecting Raynaud’s quickly and taking subsequent tests to determine if a patient has a more serious condition, such as Systemic Sclerosis, is incredibly important. Such conditions should not be left undiagnosed, as they can significantly affect the internal organs of the body as well as the skin. Raynaud’s can be an early symptom of such an underlying condition.

The new technology will also help us to study conditions such as diabetes and cancer in novel ways. Our tests are not only about the diagnostic techniques themselves, but also to make them more affordable and accessible and therefore more likely to be adopted by healthcare providers. We will be working alongside UHCW and other national and international collaborators to inform this aspect of our research.

Professor John Allen, Centre for Intelligent Healthcare

Find out more about the Centre for Intelligent Healthcare.