Professor Derek Renshaw

Derek graduated with a PhD from the Department of Endocrinology at Bart's and The London School of Medicine and Dentistry, Queen Mary University of London in 2001. Since then he has completed post-doctoral posts within the University of London in areas including wound healing, appetite regulation and inflammation.

Derek works on models of inflammation and particularly the area of pro-resolution with a focus on Annexin A1 protein. He secured a lecturership in physiology at the University of Westminster in September 2007 and began to develop an independent academic research career. Derek continued to work in the area of inflammation and pursued a number of research areas including work on salivary biomarkers, the inflammation associated with adiposity and the use of anti-inflammatory substances as therapeutic agents. 

Derek has also led a number of commercialization projects including a wound healing project investigating novel combinations of peptides in human tissue repair. Another externally funded project involved the development of a micro-particle based nutrient delivery platform for the oral delivery of iron. Derek was also Lead Academic of a Technology Strategy Board (now Innovate UK) funded Knowledge Transfer Partnership (KTP) grant between the University of Westminster and Nelsons Spatone®. In recognition of his achievements in the area of enterprise in January 2012 Derek was awarded the School of Life Sciences Entrepreneurial Prize Fellowship, which involved the co-ordination and academic leadership of all enterprise activities within the School of Life Sciences at the University of Westminster. Recently Derek joined the Centre for Applied Biological and Exercise Sciences at Coventry University as Professor of Translational Physiology and now provides academic leadership for the theme of Health and Disease within the research centre.

• Mehta, K., Greenwell, P., Renshaw, D., Busbridge, M., Garcia-Maya, M., Farnaud, S., and Patel, V. (2015) ‘Characterisation of hepcidin response to holotransferrin treatment in CHO TRVb-1 cells’. Blood Cells, Molecules and Diseases 55 (2), 110-118.
• Zupančič, Š., Kocbek, P., Zariwala, M.G., Renshaw, D., Orlu Gul, M., Elsaid, Z., Taylor, K.M.G., and Somavarapu, S. (2014) ‘Design and Development of Novel Mitochondrial Targeted Nanocarriers, DQAsomes for Curcumin Inhalation’. Molecular Pharmaceutics 11 (7), 2334-2345.
• Zariwala, M.G., Farnaud, S., Merchant, Z., Somavarapu, S., and Renshaw, D. (2014) ‘Ascorbyl palmitate/DSPE-PEG nanocarriers for oral iron delivery: Preparation, characterisation and in vitro evaluation’. Colloids and Surfaces B: Biointerfaces 115, 86-92.
• Zariwala, M.G., Somavarapu, S., Farnaud, S., and Renshaw, D. (2013) ‘Comparison study of iron preparations using a human intestinal model’. Scientia Pharmaceutica, 81 (4), 1123-1139.
• Zariwala, M.G., Elsaid, N., Jackson, T.L., López, F.C., Farnaud, S., Somavarapu, S., and Renshaw, D. (2013) ‘A Novel approach to oral iron delivery using ferrous sulphate solid lipid particles’. Int J. Pharmaceutics 456 (2), 400-407.
• Fowkes, R.C., Moradi-Bidhendi, N., Brancaleone, V., Zariwala, M.G., Brady, D., Jessop, D.S., Flower, R., Perretti, M., and Renshaw, D. (2013) ‘Annexin A1 protein and its relationship to cortisol in human saliva’. Psychoneuroendocrinol 38 (5), 722-727.
• Kosicka-Knox, A., Cunliffe, A., Mackenzie, R., Zariwala, M.G., Perretti, M., Flower, R., and Renshaw, D. (2013) ‘Attenuation of plasma annexin A1 in human obesity’. FASEB J 27 (1), 368-378.
• Elliott, B., Renshaw, D., Getting, S., and Mackenzie, R. (2012) ‘The central role of myostatin in skeletal muscle and whole body homeostasis’. Acta Physiol. 205 (3), 324-340.
• Holloway, P.M., Smith, H.K., Renshaw, D., Flower, R.J., Getting, S.J., and Gavins, F.N. (2010) ‘Targeting the melanocortin receptor system for anti-stroke therapy’. Trends Pharmacol Sci. 32 (2), 90-98.
• Renshaw, D., Montero-Melendez, T., Dalli,  J., Kamal,  A., Brancaleone,  V., D’Acquisto,  F., Cirino, G., and Perretti, M. (2010) ‘Downstream gene activation of the receptor ALX by the agonist annexin A1’. PLoS ONE 5 (9), e12771.
• Tripatara, P., Patel, N., Brancaleone, V., Renshaw, D., Rocha, J., Sepodes, B., Mota-Filipe, H., Perretti, M., and Thiemermann, C. (2009) ‘Characterisation of Cystathione Gamma-Lyase/Hydrogen Sulphide Pathway in ischaemia/reperfusion injury of the mouse kidney: an in vivo study’. Eur J Pharmacol. 606 (1-3), 205-209.
• Dalli, J., Norling, L.V., Renshaw, D., Cooper, D., Leung, K.Y., and Perretti M. (2008) ‘Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles’. Blood 112 (6), 2512-2519.

• Characterisation of iron absorption from Spatone in an in vitro model of intestinal absorption. Knowledge Transfer Partnership (KTP).
• Accelerated Wound Healing. Commercialisation grant.
• Micronutrient Delivery Platform (MDP) for targeted iron delivery. Commercialisation grant.
• Entrepreneurial Prize Fellowship Award. Personal award to support enterprise activities.
  
• The role of endogenous anti-inflammatory substances in human adiposity. Research project (MPhil).
  
• Dehydroepiandrosterone steroids are regulators of immune function via leukocyte Annexin-A1. Small Grant Programme.
  
• Investigation of the physiological role of salivary Annexin-A1 protein. New investigator award (Institutional).
  
• The Role of Adrenomedullin in Tissue Injury Repair.
  
• Biomagnets: A novel tutorial aid for visual learners. Project to develop a tutorial teaching aid.
  
• Expansion of sample handling in Centre for Applied Biological and Exercise Sciences. Equipment grant to supply the new ABES Research Centre.