Development of a novel human ventricular myocyte in-silico mathematical model in healthy and diseased conditions
Eligibility: UK/EU/International graduates with the required entry requirements
Funding details: Bursary plus tuition fees (UK/EU/International)
Duration: Full-Time – between three and three and a half years fixed term
Application deadline: 31 May 2021
Interview dates: Will be confirmed to shortlisted candidates
Start date: September 2021
For queries contact: Professor Helen Maddock
Coventry University is inviting applications from suitably-qualified graduates for a fully-funded PhD studentship with the Centre for Sport, Exercise and Life Sciences.
Current efforts investigating drug effects on cardiac function in normal/diseased conditions at both electrical and mechanical levels are hampered by the lack of fundamental information of human cardiac function.
Although current in-vitro techniques provide some understanding of cardiovascular physiology, data from these models cannot be definitely translated to the human situation. Access to normal and diseased human heart samples is extremely difficult and variable. In order to treat human cardiopathological conditions (i.e heart failure) via hypothesis-driven strategies, it is imperative data is obtained on electrical and mechanical function using clinically relevant, non-clinical human myocardial in-silico mathematical models. We will learn critical information on how human myocardium behaves functionally in health and disease, supporting novel drug discoveries for cardiovascular disease therapies such as heart failure.
We will take an interdisciplinary approach, combining mathematics, biophysics, engineering and cardiac physiology/pharmacology building on complementary skills of the supervisory team to improve our modeling capacity to predict drug responses in healthy and disease conditions. This proposal addresses UK sustainable development goal Good Health and Well-being while aligning with global strategies promoting challenge-led disciplinary and interdisciplinary research.
The outcomes from this study will aid the development of significantly improved treatment for patients with cardiac diseases.
This is a fully-funded studentship including full tuition fees (UK/EU/International) plus stipend (based upon the applicable UKRI rate at the point of the award) and additional allowances.
The successful candidate will receive comprehensive research training including technical, personal and professional skills.
All researchers at Coventry University (from PhD to Professor) are part of the Doctoral College and Centre for Research Capability and Development, which provides support with high-quality training and career development activities.
- A minimum of a 2:1 first degree in a relevant discipline/subject area with a minimum 60% mark in the project element or equivalent with a minimum 60% overall module average.
PLUS the potential to engage in innovative research and to complete the PhD within a 3.5 years.
- A minimum of English language proficiency (IELTS overall minimum score of 7.0 with a minimum of 6.5 in each component.
How to apply
All applications require full supporting documentation, a covering letter, plus a 2000-word supporting statement showing how the applicant’s expertise and interests are relevant to the project.Apply to Coventry University