Development of a novel human ventricular myocyte in-silico mathematical model in healthy and diseased conditions

Eligibility: UK/EU/International graduates with the required entry requirements 

Funding details: Bursary plus tuition fees (UK/EU/International)

Duration: Full-Time – between three and three and a half years fixed term

Application deadline: 31 May 2021

Interview dates: Will be confirmed to shortlisted candidates

Start date: September 2021

For queries contact: Professor Helen Maddock

GCRF PhD Studentships

This is a GCRF fully-funded PhD studentship.

See the full list of available opportunities

 


Introduction

Coventry University is inviting applications from suitably-qualified graduates for a fully-funded PhD studentship with the Centre for Sport, Exercise and Life Sciences

Project Details

Current efforts investigating drug effects on cardiac function in normal/diseased conditions at both electrical and mechanical levels are hampered by the lack of fundamental information of human cardiac function.

Although current in-vitro techniques provide some understanding of cardiovascular physiology, data from these models cannot be definitely translated to the human situation. Access to normal and diseased human heart samples is extremely difficult and variable. In order to treat human cardiopathological conditions (i.e heart failure) via hypothesis-driven strategies, it is imperative data is obtained on electrical and mechanical function using clinically relevant, non-clinical human myocardial in-silico mathematical models. We will learn critical information on how human myocardium behaves functionally in health and disease, supporting novel drug discoveries for cardiovascular disease therapies such as heart failure.

We will take an interdisciplinary approach, combining mathematics, biophysics, engineering and cardiac physiology/pharmacology building on complementary skills of the supervisory team to improve our modeling capacity to predict drug responses in healthy and disease conditions. This proposal addresses UK sustainable development goal Good Health and Well-being while aligning with global strategies promoting challenge-led disciplinary and interdisciplinary research.

The outcomes from this study will aid the development of significantly improved treatment for patients with cardiac diseases.

Funding

This is a fully-funded studentship including full tuition fees (UK/EU/International) plus stipend (based upon the applicable UKRI rate at the point of the award) and additional allowances.

Benefits

The successful candidate will receive comprehensive research training including technical, personal and professional skills.

All researchers at Coventry University (from PhD to Professor) are part of the Doctoral College and Centre for Research Capability and Development, which provides support with high-quality training and career development activities.

Entry requirements

  • A minimum of a 2:1 first degree in a relevant discipline/subject area with a minimum 60% mark in the project element or equivalent with a minimum 60% overall module average.
    PLUS the potential to engage in innovative research and to complete the PhD within a 3.5 years.
  • A minimum of English language proficiency (IELTS overall minimum score of 7.0 with a minimum of 6.5 in each component.

How to apply

All applications require full supporting documentation, a covering letter, plus a 2000-word supporting statement showing how the applicant’s expertise and interests are relevant to the project.

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