Coventry University | Dr. Afthab Hussain
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Dr. Afthab Hussain

Senior Lecturer

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My Research Vision

The objectives of my research are to understand the physiological, cellular and intracellular processes that are involved in myocardial injury following a heart attack or via drug induced myocardial impairment of myocardial function. Furthermore, to determine physiologically or pharmacologically feasible adjunctive therapies that can protect the heart from injury and preserve function in young and aged models of cardiovascular disease. The key aim of my research is to translate our research from ‘benchside' to 'bedside’. 

Biography

Dr Hussain has published numerous articles in the field of cardiovascular research and presented his research at both national and international conferences. He has supervised several PhD and MRes students during his time at Coventry University.

Selected Outputs

  • Lee, B.J., Emery-Sinclair, E.L., Mackenzie, R.W., Hussain, A., Taylor, L., James, R.S., and Thake, C.D. (2014) ‘
  • The impact of submaximal exercise during heat and/or hypoxia on the cardiovascular and monocyte HSP72 responses to subsequent (post 24 h) exercise in hypoxia. Extreme Physiology & Medicine 3. Available from http://dx.doi.org/10.1186/2046-7648-3-15 
  • Babba, M., Janneh, O., Maddock, H., and Hussain, A. (2013) ‘The anti-cancer drug Artemisinin protects against myocardial ischaemia-reperfusion injury via the recruitment of PI3K-AKT-p70S6k cell survival pathway’. Cardiovascular Research 103 (S1), S102-S141. Available fromhttp://dx.doi.org/10.1093/cvr/cvu098.89
  • Gharanei, M.,  Hussain, A., James, R., Janneh, O., and Maddock, H. (2014) ‘Investigation into the cardiotoxic effects of doxorubicin on contractile function and the protection afforded by cyclosporin A using the work-loop assay’. Toxicology in Vitro 28 (5), 722-731. Available fromhttp://dx.doi.org/10.1016/j.tiv.2014.01.011.
  • Gharanei, M., Hussain, A., Janneh, O., and Maddock, H. (2014) ‘Inhibition of the mitochondrial permeability transition pore with cyclosporin A protects against doxorubicin-induced cardiotoxicity’ Journal of Pharmacological and Toxicological Methods 70 (3), 329. Available from http://dx.doi.org/10.1016/j.vascn.2014.03.071
  • Harvey, K., Hussain, A., and Maddock, H. (2014) ‘Ipratropium Bromide Mediated Myocardial Injury in In Vitro Models of Myocardial Ischaemia/Reperfusion’. Toxicological Sciences 138 (2), 457-467. Available from http://dx.doi.org/10.1093/toxsci/kfu001
  • Hussain, A., Gharanei, M., Nagra, A., and Maddock, H. (2014) ‘Caspase Inhibition Via A3 Adenosine Receptors: A New Cardioprotective Mechanism Against Myocardial Infarction’.Cardiovascular Drugs and Therapy 28 (1), 19-32. Available fromhttp://dx.doi.org/10.1007/s10557-013-6500-y
  • Gharanei, M., Sandhu, H., Iqbal, S., Husseini, K., Al-Mafrachi, D., Hussain, A., and Maddock, H. (2013) 'MiRNA expression profile of imatinib myselate-induced cardiotoxicity'. Journal of Pharmacological and Toxicological Methods 68 (1), e27-e28. Available fromhttp://dx.doi.org/10.1016/j.vascn.2013.01.104
  • Gharanei, M., Hussain, A., Janneh, O., and Maddock, H. (2013) 'Attenuation of doxorubicin-induced cardiotoxicity by mdivi-1: a mitochondrial division/mitophagy inhibitor'. PLoS ONE 17 (8), e77713. Available from http://dx.doi.org/10.1371/journal.pone.0077713
  • Amewu, R.K., Chadwick, J., Hussain, A., Panda, S., Rinki, R., Janneh, O., Ward, S.A., Miguel, C., Burrell-Saward, H., Vivas, L., and O'Neill, P.M. (2013) 'Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers'. Bioorganic and Medicinal Chemistry Letters 21 (23), 7392-7397. Available fromhttp://dx.doi.org/10.1016/j.bmc.2013.09.047
  • Gharanei, M., Hussain, A., Janneh, O., and Maddock, H.L. (2013) 'Doxorubicin-induced myocardial injury is exacerbated following ischaemic stress via opening of the mitochondrial permeability transition pore'. Toxicology and Applied Pharmacology 268 (2), 149-156. Available from http://dx.doi.org/10.1016/j.taap.2012.12.003
  • La Pensée, L., Sabbani, S., Sharma, R., Bhamra, I., Shore, E., Chadwick, A.E., Berry, N.G., Firman, J., Araujo, N.C., Cabral, L., Cristiano, M.L., Bateman, C., Janneh, O., Gavrila, A., Wu, Y.H., Hussain, A., Ward, S.A., Stocks, P.A., Cosstick, R., and O'Neill, P.M. (2013) 'Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation'. ChemMedChem 8 (5), 709-718. Available fromhttp://dx.doi.org/10.1002/cmdc.201200536
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Senior Lecturer

Building: James Starley Building
Room: JS15
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