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Prostate Cancer UK
Coventry University, University of Birmingham; King’s College London; University Hospitals Birmingham
Prostate cancer survivors receiving longterm androgen deprivation therapy (ADT) sometimes experience unpleasant and debilitating side-effects, including decline in some thinking abilities. Prostate cancer patients are being observed to help us understand the factors that contribute to the risk of developing these effects on thinking – or the ability to resist them.
The aim of this project is to identify which thinking skills are affected by androgen deprivation therapy (ADT) and whether some people are more at risk of decline in thinking skills performance. This will be done by following patients who do and who do not receive ADT for an 18 month period. This is an innovative project combining: (1) cognitive testing (tests of thinking skills such as memory), (2) psychosocial measures (e.g. mood, fatigue), (3) brain imaging and (4) blood biomarkers (to assess testosterone levels and genetic risk of cognitive decline).
The study will allow us to record potential risk factors prior to starting ADT to identify baseline factors that predict performance on tasks at follow-up. The study offers a unique opportunity to develop a risk profile for cognitive decline (changes in thinking skill) in men receiving ADT that could be used by treating doctors.
Currently, we do not have a clear understanding of the factors that might make patients receiving ADT more at risk to changes in thinking skills (for example, age-related brain changes), or whether there are protective factors that might make a person more resilient to these changes (for example, good psychosocial status). By providing this information, our study would offer men and their prescribing doctors evidence-based information to support decision-making. It would also allow us to develop specific, focused interventions to mitigate the impact of changes in thinking skills on everyday functioning (for example, through strategies to improve memory or aid planning skills).
The Centre for Technology Enabled Health Research (CTEHR) is delighted that Dr Katherine Brown, Reader in eHealth and Behaviour Change with CTEHR, will be presenting a seminar as part of its 2017 internal seminar series.
Dr David Ellard, Warwick Medical School - Warwick Clinical Trials Unit - University of Warwick, will be CTEHR’s next speaker on 31st January 1-2pm. Please see below for more information.
The Centre for Technology Enabled Health Research (CTEHR) have been involved in an innovative project launched by BBC Learning and the Wellcome Trust which is designed to get primary school children excited about science.
As part of a new strategy in Leicester, UK, people born overseas will be offered testing for certain infectious illnesses (tuberculosis, HIV and viral hepatitis) when they register with a GP in the city. We aim to find out whether offering early tests for these infectious illnesses in this way will result in GPs actually doing more tests and identifying more people with these infectious illnesses.
Delivering Excellent Care Every Day for People Living with Advanced Dementia: Namaste Care Intervention UK (2016-19) is led by the Association for Dementia Studies at the University of Worcester & focuses on developing the optimal every-day care intervention for people with advanced dementia in care homes based on the principles of Namaste Care developed by Joyce Simard.