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This theme aims to characterise and manipulate key cellular and molecular systems which underlie normal and pathological cell function.
One area of research within this theme looks to examine and understand the role of ageing in the decline of the regenerative capacity of the liver and its role in liver related diseases.
Many organ systems exhibit significant age-related deficits, but, based on studies in old rodents and elderly humans, the liver appears to be relatively protected from such changes.
A remarkable feature of the liver is its capacity to regenerate its mass following partial hepatectomy. Reports suggest that ageing compromises the liver’s regenerative capacity, both in the rate and to the extent the organ’s original volume is restored. In addition to this, no liver disease is specific to old age; however, as the population ages geriatricians are frequently managing older patients with chronic liver diseases. Understanding the effects of ageing on the liver will hopefully help give insight into the fundamental cellular and molecular mechanisms involved in this organ’s unique regenerative abilities and how they are then subverted in age-related liver disorders such that novel therapies can be applied to their treatment.
The goal of the project is to identify and subsequently characterise the dsRNA dimension of the animal gut microflora (both the differential presence of antisense bound to mRNA and phage dsRNAs containing novel genetic information in response to AB pressure). Identification of novel functional dsRNAs (asRNA bound to its target and phage dsRNAs involved in AR) will mark a paradigm shift in our understanding of the development of AR and future approaches to treating infections.
InoCardia: Novel human-cell based assay for assessment of cardiovascular liability.
Dr Christopher Mee's project looking at the ability of the liver to fully regenerate after injury.
Dr Michael Duncan's project to understand how early development of fundamental movement skills might impact on physical activity and body fatness in British children.